Kazuo Nagai Selected Research

acetoxycycloheximide

2/2009	Caspase-8 mediates mitochondrial release of pro-apoptotic proteins in a manner independent of its proteolytic activity in apoptosis induced by the protein synthesis inhibitor acetoxycycloheximide in human leukemia Jurkat cells.
6/2008	ERK and p38 MAP kinase are involved in downregulation of cell surface TNF receptor 1 induced by acetoxycycloheximide.
4/2008	Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates TNF-alpha-mediated activation of NF-kappaB and caspase-8.
2/2005	Acetoxycycloheximide (E-73) rapidly induces apoptosis mediated by the release of cytochrome c via activation of c-Jun N-terminal kinase.

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Kazuo Nagai Research Topics

Disease

10	Bone Resorption 02/2012 - 07/2002
5	Insulin Resistance 01/2013 - 06/2009
4	Osteoporosis 01/2011 - 03/2006
4	African Trypanosomiasis (Nagana) 03/2006 - 06/2002
3	Obesity 01/2013 - 07/2011
3	Leukemia 09/2009 - 02/2005
3	Neoplasms (Cancer) 09/2009 - 02/2002
2	Body Weight (Weight, Body) 01/2013 - 07/2012
2	Hyperglycemia 07/2012 - 06/2010
2	Bone Diseases (Bone Disease) 01/2012 - 01/2010
2	Type 2 Diabetes Mellitus (MODY) 04/2011 - 06/2009
2	Carcinoma (Carcinomatosis) 06/2008 - 04/2008
2	Infections 03/2006 - 06/2003
1	Dehydration (Water Stress) 03/2013
1	Dyslipidemias (Dyslipidemia) 07/2012
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 07/2011
1	Vascular Diseases (Vascular Disease) 05/2009
1	Atherosclerosis 05/2009
1	Cryptosporidiosis 01/2004
1	Parasitemia 06/2003
1	Burkitt Lymphoma (Burkitt's Lymphoma) 02/2003
1	Necrosis 02/2003
1	Gastritis 07/2002
1	Thymoma (Thymic Carcinoma) 02/2002
1	Lymphoma (Lymphomas) 01/2002

Drug/Important Bio-Agent (IBA)

4	acetoxycycloheximideIBA 02/2009 - 02/2005
3	LigandsIBA 01/2012 - 06/2009
3	Caspase 8 (Caspase-8)IBA 02/2009 - 02/2002
2	Triglycerides (Triacylglycerol)IBA 01/2013 - 07/2012
2	Dihydrotachysterol (AT 10)IBA 01/2013 - 07/2002
2	nobiletinIBA 01/2013 - 06/2010
2	Glucose (Dextrose)FDA LinkGeneric 07/2012 - 04/2011
2	Pharmaceutical PreparationsIBA 07/2011 - 03/2006
2	AlkaloidsIBA 06/2011 - 01/2011
2	Carbolines (Beta-Carbolines)IBA 06/2011 - 01/2011
2	Harmine (Telepathine)IBA 06/2011 - 01/2011
2	ThiazolidinedionesIBA 04/2011 - 06/2009
2	Cytochromes c (Cytochrome c)IBA 09/2009 - 02/2009
2	Protein Synthesis InhibitorsIBA 02/2009 - 06/2008
2	NF-kappa B (NF-kB)IBA 06/2008 - 04/2008
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2008 - 04/2008
2	Glycerol (Glycerine)FDA LinkGeneric 03/2006 - 06/2003
2	ascofuranoneIBA 03/2006 - 06/2003
2	alternative oxidaseIBA 09/2003 - 06/2002
2	Cyanides (Isocyanides)IBA 09/2003 - 06/2002
2	Oxidoreductases (Dehydrogenase)IBA 09/2003 - 06/2002
2	Troleandomycin (TAO)FDA Link 09/2003 - 06/2002
2	Fas Ligand Protein (Fas Ligand)IBA 02/2002 - 01/2002
1	LigninIBA 03/2013
1	fargesinIBA 07/2012
1	Fatty Acids (Saturated Fatty Acids)IBA 07/2012
1	LignansIBA 07/2012
1	biselyngbyasideIBA 02/2012
1	coptisineIBA 01/2012
1	artepillin CIBA 04/2011
1	Propolis (Bee Bread)IBA 04/2011
1	AdipokinesIBA 06/2010
1	p38 Mitogen-Activated Protein KinasesIBA 01/2010
1	palmatineIBA 01/2010
1	honokiolIBA 01/2010
1	LuteolinIBA 12/2009
1	CaspasesIBA 09/2009
1	FD 891IBA 09/2009
1	MacrolidesIBA 09/2009
1	PPAR gammaIBA 06/2009
1	magnololIBA 06/2009
1	Platelet-Derived Growth FactorIBA 05/2009
1	AntioxidantsIBA 05/2009
1	Becaplermin (PDGF-BB)FDA Link 05/2009
1	chrysoeriolIBA 05/2009
1	Apoptosis Regulatory ProteinsIBA 02/2009
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 06/2008
1	Cycloheximide (Cicloheximide)IBA 06/2008
1	reveromycin AIBA 03/2006
1	Protons (Proton)IBA 03/2006
1	Isoleucine-tRNA LigaseIBA 03/2006
1	Carboxylic AcidsIBA 03/2006
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 09/2004
1	Hydroxyl RadicalIBA 09/2004
1	QuercetinIBA 04/2004
1	Penicillic AcidIBA 02/2003
1	Calcitriol (Calcijex)FDA LinkGeneric 02/2003
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 02/2003
1	Transforming Growth Factor beta (TGF-beta)IBA 02/2003
1	BE 18591IBA 07/2002
1	LipopolysaccharidesIBA 07/2002
1	IonophoresIBA 07/2002
1	Concanavalin AIBA 07/2002
1	CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)IBA 02/2002
1	Death Domain ReceptorsIBA 02/2002

Therapy/Procedure

3	Drug Therapy (Chemotherapy) 03/2006 - 06/2003
1	Therapeutics 04/2008